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New england journal of medicine8/6/2023 Case Records of the MGH – follow expert physicians’ decision-making, differential diagnoses, and treatment options of actual cases.Interactive Medical Cases – virtually manage an actual peer-reviewed case.Videos in Clinical Medicine – concise reviews of more than 92 clinical procedures including preparation, equipment, and more.Quick Take video animations – two-minute summaries of key findings.Research Summaries – brief one-page overviews of clinical studies’ results, conclusions, and limitations.He is the Vice-Chair for Research for the Department of Obstetrics & Gynecology and the Medical Director for Statewide Research for the Indiana Clinical and Translational Sciences Institute. All of these are focused on improving obstetric and newborn outcomes. Haas’ research at IU is mostly focused on obstetrics, encompassing many areas, with particular interest in medications in pregnancy and biobanks. ![]() There was an almost 20 percent decrease in pregnancy complications for women treated with medication compared to the standard group: Severe preeclampsia was reduced from 29 to 23 percent and preterm births before 35 weeks’ gestation were significantly reduced, from more than 16 to 12 percent. Participants were evaluated in routine clinic visits through six weeks after delivery. The standard group received medication only if a participant developed more severe hypertension, or a blood pressure greater than 160/105 mmHg. The active group was prescribed blood pressure medication, mostly labetalol or nifedipine, to keep blood pressure below 140/90 mmHg. Participants were randomized into active and standard treatment groups. The Black patient population is disproportionately affected by chronic hypertension, and almost 50 percent of study participants were Black. ![]() ![]() Notably, the CHAP trial is one of the most comprehensive and diverse studies of its kind. From September 2015 to March 2021, CHAP enrolled more than 2,400 pregnant women with known mild chronic hypertension, whose blood pressure was greater than 140/90 mmHg but less than 160/105 mmHg. The CHAP consortium launched in 2014 with funding from the National Institutes of Health’s Heart, Lung and Blood Institute. We welcome all nominations regardless of trial setting, investigator, or patient group. Consistent with the overall aims of the Society, we support the goals of equity, diversity, and inclusion. The presentation of its design, execution, and results is a model of clarity and intellectual soundness. Reflects expertise in subject matter, excellence in methodology, and concern for study participants. Provides the basis for a substantial, beneficial change in health care. Nominations are submitted by SCT members, investigators and interested scholars from around the world, and the award is presented to the trial that fulfills the following standards: The work garnered the CHAP trial a nomination for the David Sackett Trial of the Year. The findings provided for the first time comprehensive, evidence-based data for treating non-severe forms of chronic hypertension during pregnancy. Results from the CHAP trial – which were published in the New England Journal of Medicine in April 2022 – showed that treating mild chronic hypertension with medications is safe. While medical professionals agreed that severe chronic hypertension during pregnancy should be treated with medications, they were divided for decades over whether to treat non-severe or mild forms of chronic hypertension during pregnancy. More than 2 percent of pregnant women in the United States have chronic hypertension, or high blood pressure. Munsick Professor of Obstetrics and Gynecology, led the work of the collaborators at Indiana University. Heersink School of Medicine, University of Alabama at Birmingham.ĭavid M. ![]() The results from the CHAP trial consortium come from more than 60 clinical sites across the United States, led by Alan Tita, MD, PhD, the Senior Vice Chair for Research and Innovation, Department of Obstetrics and Gynecology, Center for Women’s Reproductive Health, Marnix E. The award is given annually to the leaders of one randomized, controlled study that has provided a substantial change to the healthcare field. The Chronic Hypertension and Pregnancy (CHAP) trial was given the David Sackett Trial of the Year award by SCT, a celebrated international organization of professional researchers. A study co-authored by an Indiana University School of Medicine faculty member, which showed treating even mild preexisting high blood pressure during pregnancy improves maternal and fetal outcomes, has been named Clinical Trial of the Year by the Society of Clinical Trials (SCT).
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